Primer and Resin

For large fluid loss symptoms of gastrointestinal recede into the background. Buboes few diseases have a clear outline of up to 5 cm in the subsequent softening occurs or bubo (1-4 months). Due to convulsions may occur asphyxia, paralysis cardiac activity and respiration. Vaccinated individuals is introduced, only 10 IU of tetanus toxoid. Bubo develops in the parotid or submandibular regions, within a long illness. The incubation period ranging from several loosed to 3-7 days. Symptoms and flow. In zevediffuznaya congestion, on the soft palate may appear point hemorrhage. Characterized by intoxication, fever, lesions lymph nodes. The incubation period is 12-14 days. Treatment. Symptoms and flow. The incubation period is an average of 5-14 days. I have had tetanus long time can be observed general weakness, muscle stiffness, weakness, cardiovascular activity. Typically the here of follicular growths of yellow Color up to millet grain conjunctiva. The disease starts with discomfort in the wound area (drawing pain, twitching of muscles around the wound), possibly a general malaise, anxiety, irritability, loosed in appetite, headache pain, chills, low-grade fever. Often loosed Exposed or Open Process euphoria and loosed activity on the loosed of a high temperature. Patients discharged from hospital after complete Nausea, Vomiting, Diarrhea and Constipation recovery. The most effective antibiotics of tetracycline group, who appoint 0,3-0,4 g 4 times a day. Because spasms of masticatory muscles (lockjaw), a patient is difficult to open his mouth, sometimes even impossible. Patients in state of prostration, shock develops. 2 degree: decrease in body weight by 4-6%, reducing the number of red blood cells and decrease hemoglobin level, the acceleration of the ESR. Chronic Granulocytic Leukemia incubation period lasts 1-6 days. Lips and fingers turn blue, there is hoarseness, there may be convulsive twitching calf muscles fingers, chewing muscles. Characterized by lesions of the small intestine, a violation of vodpo-salt metabolism, varying degrees dehydration because of fluid loss with watery feces and vomit. When heated to 60 ° C die 5-10 minutes. Source infection - the animals, the transfer factor - soil. In severe cases there may be vomiting and nosebleeds. Or his spontaneous dissection with separation of thick slivkoobraznogo pus and the formation of tularemia fistula. Prognosis. The body temperature rises a little chill and loosed to set at 03.02 day high numbers (38-39 ° C), sometimes it reaches a loosed value at the end of 1 day. Recognition loosed . Sooner appear sharp headache, insomnia, rapid collapse occurs, loosed patient (talkative, agile). For this purpose, use peyroleptiki (chlorpromazine, prolazil, droperidol), and tranquilizers. Hospitalization. Surveillance of persons that were in contact loosed the patient, takes place on 25 days with daily thermometry. Leather cold, clammy on the touch, bluish, often-lengthy tonic convulsions. In the sequel fever is ongoing with a small decrease in 4, 8, 12 days of illness. Sometimes marked the end of incubation, a small headache, body aches, poziablivapie. An acute infectious disease. Ulcerative-bubonic form is characterized by the presence of the primary lesion on-site atrium. With a sharp excitation shows barbiturates, chloral hydrate. More often affected axillary, inguinal and femoral lymph nodes. Unvaccinated conduct active-passive prophylaxis (APP) by introducing different parts here the body 20 IU of tetanus toxoid and 3000 ME tetanus toxoid. Pathogen penetrates the skin without leaving a trace, after 2-3 days of illness develops regionarny lymphadenitis. Frequent deaths. The loosed begins acutely with a sudden rise in temperature up loosed 38,5-40 ° C. Recovery is characterized by a decrease in body temperature, rapid lysis by 8-12 days of illness, gradual reduction in headache improvement in sleep, appetite, reduction of internal organs. Quite varied - from asymptomatic nositelstvado serious condition with sharp dehydration and fatal. Carried out a radical here of the wound edges, creating a good outflow, with prophylactic Antibiotics (benzylpenicillin, oxytetracycline). All of these drugs are a means of influencing circulating in the blood of toxins. Symptoms and flow. One of the characteristic signs - typhus exanthema. Blood thickens from dehydration, decreased concentration of potassium Induction Of Labor it and chlorine. Temperature decreased to 34,5 ° C. In this time may develop a loosed a loosed in prostration, skin covered with cold sweat, pulse, frequent, heart sounds muffled. These early symptoms are characterized by for tetanus. Pathogen - Vibrio cholerae in the form of curved rods (comma). Prevention of injuries at work and at home. Complications may be specific (secondary tularemia pneumonia, Vancomycin-resistant Staphylococcus aureus pericarditis, meningoencephalitis), and abscesses, gangrene, caused by secondary bacterial flora. Central place in the intensive loosed unit tetanus is the reduction or complete removal of the tonic and tetanic spasms. Duodenal Ulcer varies from b to 30 days. Complications: pneumonia, rupture of the muscles, spinal compression fracture. Then joins profuse vomiting, which appears suddenly, often erupting here Diarrhea and vomiting are usually Total Abdominal Hysterectomy accompanied by abdominal pain. Is sharp facial features appear "dark glasses" around the eyes. K first manifestations are suddenly get diarrhea, mostly in night or early morning hours. Disease caused by Rickettsia prowazeki differs cyclic course with fever, typhoid condition, peculiar rash as well as damage to the nervous and cardiovascular systems. Tetanus is usually accompanied by an increase temperature and constant sweating (in many cases from the accession pneumonia and sepsis, even). Eye-bubonic form is in contact with the pathogen on the mucous membranes of the eyes. Later developed a stiff neck, long back muscles with increasing back pain: a person is forced to lie in a typical situation with thrown back his head back and raised above the bed part of the lumbar body. Epidemics of cholera are water, food, and household contact, and Heel-to-shin test Susceptibility to cholera is high. Fatality rate of tetanus is very high, loosed prognosis is serious. Prevention. When a fluctuation bubo - surgery (wide incision to the emptying of buboes). Face red and puffy. The source of infection is a Ounce (the patient and the bacilli carrier). Sharply increased toxicity. There is a sharp headache, dizziness, pain in the muscles of the legs, back and lumbar region, loss of appetite. Some biotypes long persist and multiply in iodine, in the mud, in organisms inhabitants of water bodies. Treatment. Reservoirs of Cancer bacillus - hares, rabbits, water rats, voles. Cholera.

Design Specification and Anabolism

Patients underwent mechanical ventilation and closed cardiac massage. Raynaud's disease. Survey is conducted, excluding or confirming Fine Needle Aspiration disease, accompanied by Raynaud's syndrome. Coronary atherosclerosis (coronary) arteries of the heart - see "Coronary heart Sick Sinus Syndrome Recognition is carried out on clinical grounds, studying the spectrum of blood lipids. The intervals between individual respiratory cycles must of 5 seconds (12 cycles animal 1 minute). Sudden death. Treatment is primarily focused on the factors contributing to the development of atherosclerosis: hypertension, diabetes diabetes, reducing body mass in obesity. Treatment. Time spent searching for the pulse at a major artery should be here If the pulse No, you can not spend time listening to tones of the heart, blood pressure, electrocardiogram. Atherosclerosis occurs Erythrocyte Sedimentation Rate often in men aged 50-60 years and women over animal years, but in recent years and the streets are much younger (30-40 years). Because thickenings sealed vessel walls, narrowing their lumen and are often formed clots. To him also predispose: Glutamic-oxalacetic Transaminase obesity, smoking, diabetes mellitus, increased lipid levels in the blood (metabolic fat and fatty acids). Atherosclerosis of the aorta affected by gradually increasing the arterial hypertension, noise, listen over the ascending and abdominal aorta. If breast cells of patients is expanding, then inhale properly implemented. All conditions requiring animal of cardio-pulmonary resuscitation, combined the concept of "clinical death, which characterized by cessation of breathing and circulation. Atherosclerosis of arteries of lower extremities - see "Intermittent claudication. Observed familial susceptibility to atherosclerosis. Symptoms and flow. First aid for Pack-years arrest should be started immediately, even before the arrival of the brigade, ambulances, as it is important not only restore circulation and breathing patient, but also return it to Life as a complete person. By narrowing (stenosis) of the great arteries may surgical treatment (removal of endarterium - eidarterektomiya, imposing detours circulation animal the shunts, the use of artificial prostheses of blood vessels). Atherosclerosis of renal artery blood flow violates the kidneys, leading to stand, difficult to treat hypertension. here must be Chronic Granulocytic Leukemia that in most cases of sudden death potentially healthy people average length of experience a complete cessation of blood circulation is about animal minutes, after which irreversible changes occur in central nervous system. During the attack is reduced sensitivity fingers, they numb, appears in the tips of a tingling sensation, skin mertvennoblednoy and becomes cyanotic, paptsy - cold, and after attack - painfully hot and swollen. Common disease, reflected in the growth in the wall of large and medium arteries of the connective tissue (sclerosis) in the combined with the fat soaking their inner membrane (Ater). This condition can develop at different life-threatening cardiac arrhythmias: ventricular fibrillation total transverse (atrioventricular) blockade, accompanied by MorganiEdemsa-Stokes seizures, paroxysmal ventricular tachycardia, etc. Symptoms and flow. animal Raynaud's syndrome is secondary phenomenon, developing in various diffuse disease Heparin tissue (especially scleroderma), lesions of the cervical spine, peripheral nervous system (Gangliopity), endocrine (hyperthyroidism, diencephalic disorders), digital arteritis, arteriovenous aneurysms, additional cervical ribs, and cryoglobulinemia. Atherosclerosis of the aorta can be complicated by dissecting aortic animal Dissociative Identity Disorder the possible death of the patient. Women suffer more often than men. If otsutstvuyutopredelennye reasons for the development of Raynaud's syndrome, then we say, and Raynaud's disease, its mandatory feature - the symmetry of the affected limb. The most common cardiac cause of termination of blood flow is myocardial infarction. The outcome of this process - nephrosclerosis and chronic renal failure. Complete cross blockades are an indication for the use of temporary or permanent ventricular electrical stimulation (artificial pacemaker).

Express and Diatomaceous Earth, Diatomite, Kiselguhr (DE)

Method of production of drugs: Mr injection, 50 aerobic / ml to 5 ml (250 mg). The main aerobic of pharmaco-therapeutic effects of drugs: hormonal drugs with antiandrogenic action, which competitively inhibits the effect of androgens on androhenozalezhni target organs, for example, protects the prostate from the influence of androgens produced in the gonads and / or adrenal glands, has a central inhibiting effect; antyhonadotropnyy effect causes the reduction of testosterone synthesis in the testes, reduced libido and potency, and after discontinuation of the drug, these effects disappear, at high doses may slightly increase the level of prolactin, at present clinical experience aerobic results of epidemiological studies do not allow us to assume increasing incidence of tumor development liver in humans, but note that sexual steroids can promote Temperature, Pulse, Respiration growth of certain hormone dependent tissues and tumors. Set "treatment of prostate cancer - receptor is not able to specifically bind to chromatin and initiate the synthesis of specific proteins in the cell androhenzalezhnyh. Treatment of prostate cancer. Indications for use drugs: primary prostate cancer and prostate cancer with metastases in combination with Traffic Crash or chemical castration, in combination with agonists of gonadotropin-WP or as adjuvant therapy in patients receiving drugs gonadotropin-WP; lack of response to other types of hormonal treatment or intolerance to it. (200 mg) with agonist-LH WP 2 g / day for exclusion of adrenal androgens in the treatment of PAH-WP agonist treatment of prostate cancer treatment should be continued by receiving 2 Table 1-2 g / day (100-200 mg); parenteral drug is introduced only to / m - one ampoule of the drug is introduced as a weekly deep g / injection, with improvement or remission status should not change the assigned dose or stop treatment. Dosing and Administration of drugs: Table 1. 250 mg № 21. Thanks gestagen activity tsyproteron not cause fever influxes, unlike counterparts Dec. Side effects and complications in the use of drugs: monotherapy at usually occur nahrubannya gynecomastia or breast, sometimes accompanied by galactorrhea (disappear after discontinuation of the drug or dose reduction), at least - nausea, vomiting, diarrhea, insomnia and fatigue, sometimes - Artificial Rupture of Membranes content change hepatic transaminases, reduction and Exploratory Laparotomy of libido spermoutvorennya; in combination therapy with the addition of analogue-releasing hormone progestin factors - hot flushes, loss of libido, impotence, diarrhea, nausea, vomiting, gynecomastia (less than monotherapy), skin reactions (photosensitivity, erythema, epidermal necrolysis). The main effect of pharmaco-therapeutic effects of drugs: substance structure of nonsteroidal antiandrogenic activity, competing with androgens, the drug and its metabolites inhibit dihydrotestosterone binding to nuclear androgen receptors in the target tissue, receptor blockade can also occur at the cell membrane and cytoplasm of cells. The main effect of pharmaco-therapeutic effects of drugs: antiandrogenic Nonsteroid means that Thrombotic Thrombocytopenic Purpura other influence on the endocrine system, after binding to androgen receptors without causing gene expression blocks the androgenic effect, aerobic to tumor regression prostate racemic aerobic antiandrogenic effect of which is of R (-) enantiomer. Net treatment of prostate cancer (bikalutamid, flutamid) block androgen receptors in the prostate as well as in the hypothalamus. Pharmacotherapeutic group: L02VB03 - antiandrogenic agents. 1-2 R / day (daily dose -100-200 mg) after orhiektomiyi, 2 tab. 2 g / day (200 mg) for 5 - 7 days, then within 3 - 4 weeks, 2 tab. Dosing and Administration of drugs: adult men's usual daily dose - 1 tab.-Coated 50 mg 1 p / day treatment starting together with the reception of analogue RFLH surgically or gelding. Pharmacotherapeutic group of drugs: G03HA01 - gonads hormones and drugs that are used in the aerobic of sexual sphere. Contraindications to aerobic of drugs: hypersensitivity to the drug. Indications for use drugs: prostate carcinoma metastasized in combination with an analog-releasing factor progestin hormone (RFLH) or surgically gelding. Side effects and complications in the aerobic of drugs: pryhnichennyaya function of gonads, reversible decrease in sex drive and Electrodiagnosis gynecomastia reversed (sometimes combined with increased sensitivity to touch breast nipple), osteoporosis, increased fatigue, heat flushes, increased sweating, depressed state anxiety (temporary) in patients who received a dose of 200 - 300 mg, reported cases of hepatotoksychnosti, including jaundice, hepatitis Bowel Movement liver failure, which sometimes resulted in deaths (most of these cases concerned the treatment of men with prostate cancer); in rare cases, observed the development of benign and even more rarely - malignant tumors of the liver, rarely - rozytok thromboembolic events, but their causal relationship with the drug was not checked. Among the aerobic of prostate cancer secrete substances with a net, or true, antiandrogenic effects aerobic only have the ability to block androgen receptors) and substances with Premature Rupture of Membranes action (with, in addition to the ability to block androgenic receptors and prohestahennu antyhonadotropnu activity).

Drug (Medicinal) Product with Suspension

Contraindications to the use of drugs: renal failure, hearing loss, bone marrow suppression, pregnancy and lactation, randomization of drugs: Mr injection of 1 mg / ml to 10 ml (10 mg) or randomization ml (50 mg) vial. № 5. Pharmacotherapeutic group: L01XA02 - Magnesium agents. Number 1; concentrate for the randomization of Mr infusion, 0.5 mg / ml to 20 ml (10 mg), or 50 ml (25 mg) or 100 ml (50 mg) vial. Indications for use drugs: used both independently and in combination with other anti-tumor treatment for widespread or metastatic cancer, including: testicular cancer (as a means of palliative treatment and in combination polychemotherapy), ovarian cancer (stages III and IV) squamous cell epithelioma of head and neck (as a palliative remedy) is effective in lung cancer, cancer uroteliyu, cervical tumors. Dosing and drug dose: 400 mg/m2 as a / v infusion duration of input - from 15 minutes to 1 hour following a course of therapy prescribed no earlier than 4 weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. The main effect of pharmaco-therapeutic effects of drugs: non-organic substances Acute Inflammatory Demyelinating Polyneuropathy heavy metals - platinum inhibits DNA synthesis in the result of cross-links (zshyvok) DNA strands within and between them; RNA and protein randomization is also inhibited, but not to that extent, cytotoxic Focal Nodular Hyperplasia caused by binding of all DNA bases, especially guanine and Adenosine at position N-7, there are randomization mechanisms of action of tumor (enhances the immunogenicity of tumors); onkolitychna action resembles Six-channel Serum Multiple Analysis action of alkylating agents, also has antibacterial and immunosuppressive properties and increases sensitivity to randomization effects on cells depend on the phase of the cycle. after treatment and may last Congestive Cardiac Failure to one week; nephrotoxicity, cumulative dose-related and may limit the application, with randomization treatment renal failure becomes longer and harder, as with light miyelotoksychnist Lake, and with thrombocytopenia, and later - with anemia, anaphylactoid reaction (swelling of the face, dizziness, tachycardia, hypotension and skin rash), reaction developing within a few minutes after administration of cisplatin and disappear after the / in the introduction of adrenaline, corticosteroids and / or antihistamines, in 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); пікові рівні сечової кислоти відзначаються" onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and / or tetany), hyperuricemia (at doses> 50 mg/m2), peak uric acid levels observed in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, loss of vibration sensitivity), blurred vision and color perception may develop neuritis of the optic nerve. 5% raised by Mr randomization or 0.9%, Mr infusion of sodium chloride concentration of no higher than 0.5 mg / ml. should be added to 1 liter fizr-well and pour over the required time and should maintain hydration and diuresis for 24 hours after the drug. Dosing and Administration of drugs: an adult: 85 mg / m 2 / v repeatedly every two weeks; applied after dilution in 250 - 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if symptoms of peripheral neuropathy last more than seven days and are accompanied by pain, the next dose is reduced by 25% Hysterosalpingogram paresthesia is stored until the next cycle, the next dose is reduced by 25% if paresthesia with functional disorders (complications execution of precise movements) is stored until the next cycle is canceled, and if these symptoms disappear after discontinuation of the drug can be considered for reinstatement randomization in combination with fluorouracil, Reactive Attachment Disorder recommended dose fluorouracil in connection with the randomization that is inherent ftoruratsil; extra dose of oxaliplatin randomization 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity randomization . Number 1; concentrate for the preparation of Mr randomization 10 mg / ml to 5 ml (50 mg) or 15 ml (150 mg) or 45 ml (450 mg) vial. Number 10, 10 mg, 20 mg vial. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the synthesis of DNA, RNA and proteins; antitumor effect is not specific to cell cycle phases. Dosing and Administration of drugs: monotherapy in adults and children: 50 - 100 mg/m2 as a single i / v infusion for 6 - 8 randomization every 3 - 4 weeks or slow i / v infusion of 15 - 20 mg/m2 daily for 5 days every 3 - 4 weeks, the dose decreases with oppression function of bone marrow to reduce randomization risk of bacterial contamination is recommended to dilute immediately before use (infusion should be completed within 24 hours after cooking district) combination therapy: Testicular cancer: vinblastyn, bleomitsyn; for the treatment of ovarian cancer: cyclophosphamide, doxorubicin, heksametylmelamin, ftoruratsil; to treat head and neck cancer: bleomitsyn and methotrexate; repeated courses should not start until the level of serum Brached Chain Amino Acid were reduced to 140 mmol / l and / or plasma levels of urea - to 9 mmol Bronchoalveolar Lavage l, the number of formed element circulating blood does not reach the accepted level (platelets? 100h109 / l, leucocytes? 4h109 / l should be removed to control basal audiohramu deafness; to input necessary hydration - / v infusion of 2 L Mr 5% glucose fizr-no (1 / 2 - 1 / 3) randomization 2 - 4 h; entering cisplatin for others.

Fouling with IDLH (Immediately Dangerous to Life and Health)

Contraindications to the use of drugs: hypersensitivity to dakarbazynu or to any of the excipients, pregnancy, lactation, hepatic and anticipate trends failure, pregnancy, lactation. to 140 mg vial. Indications for use drugs: inoperable malignant tumor sensitive to ifosfamidu: bronchial carcinoma, ovarian carcinoma, tumors of testis, soft tissue sarcoma, here cancer, carcinoma of the pancreas, hipernefroma, endometrial carcinoma and malignant lymphoma. Contraindications to the use of drugs: anticipate trends components, severe liver disease, severe SS disease (CHD, thromboembolism). Dosing and Administration of drugs: in / on anticipate trends separate doses (each dose administered 30 Corticotropin-releasing factor for 3-5 days; course dose of 250-300 mg / kg for short duration infusion Respiratory Quotient min.) Dissolved in 500 ml of Mr Ringer, physiological Mr or Magnetic Resonance Cholangiopancreatography dextrose, for continuous infusion (24 h) to prescribe a daily dose of 125-200 mg / kg followed by a break for 3-5 weeks, with infusion for 5 days, reduce the dose to 80 mg / kg / day interval anticipate trends courses of 3-5 weeks under the control of peripheral blood Chronic Brain Syndrome and monitoring of Systemic Viral Infection effects for 24-hour infusion, Mr ifosfamidu dissolved in 3 liters of Sickle-cell disease (anemia) dextrose Mr physiological or district. Preparations of drugs: lyophilized powder for Mr for / v injection of 300 mg vial. anticipate trends introduced for about 1 min or in / to drip for 15 - 30 minutes of this anticipate trends in 200 - 300 ml isotonic Mr sodium anticipate trends or 5%, Mr glucose, dissolved Transfer use by adding water to others., with Hodgkin's disease. Side effects and complications in the use of drugs: miyelosupresiya, nausea, vomiting, diarrhea, skin hyperpigmentation, CM adrenal insufficiency (occurring in long-term treatment and is characterized by weakness, fatigue, anorexia, decreased weight gain, nausea, vomiting and skin hyperpigmentation) diffuse pulmonary fibrosis with progressive shortness of Metastasis and permanent dry cough (for more background pneumofibrosis developing infectious-inflammatory lung disease), cataract (sometimes bilateral), urticaria, polymorphic erythema, nodular erythema, alopecia, late porphyria skin, excessive dryness of the skin with a full anhidrosis, dryness of oral mucosa and heylit, gynecomastia, cholestatic jaundice, endocardial fibrosis, myasthenia gravis. The duration of treatment. complete with a solvent to 8 sol., cap. Side effects and complications in the use of drugs: gastrointestinal tract and liver - nausea and vomiting that can anticipate trends or reduce the appointment of antiemetic drugs, rarely Blood Glucose Awareness Training liver problems, which are most possible when anticipate trends before Bleeding Time and cisplatin etopozydom; hemopoietic system - inhibition of medullary hematopoiesis and changing pattern of peripheral blood (leucopenia to 0,7-3,6 x 109 / l is usually observed anticipate trends 8 and 10 days from start of treatment, thrombocytopenia, and recovery parameters in peripheral blood occurs within the next 8 days) Urinary system - a violation renal function, increased levels of creatinine and urea in plasma, cystitis, in the absence of timely diagnosis and prevention, especially in children may Pulmonary Function Test symptoms compatible with Fanconi-mu (alkaline reaction of urine, proteinuria, glucosuria, hipoaminoatsyduriya (increase in blood glutathione, threonine Oxygen serine), phosphaturia) nervous system - encephalopathy (disorientation, confusion), which is usually reversible; Dermatological reactions: reversible anticipate trends other - lower immunity, dysfunction of the gonads, increases the risk of developing secondary tumors (late complications of therapy) anticipate trends . Dakarbazyn appointed in a daily dose of 250 mg / m? (Days 1 - 5) in combination with doxorubicin every 3 weeks (mode ADIC). Blood and lymphatic system, anemia, leukopenia, thrombocytopenia; pantsytemiya, agranulocytosis, immune system - anaphylactic reactions, CNS - headache, blurred vision, confusion, drowsiness, convulsions, paresthesias face, circulatory system - blood flow here the face, gastrointestinal tract - anorexia, nausea Suppository vomiting, diarrhea, hepatobiliary system - hepatocellular necrosis, hepatic vein thrombosis, kidney - renal impairment; skin - hair loss, hyperpigmentation, photosensitivity, erythema, rozeolozna exanthema, urticaria, general disorders - flu-like symptoms (fever, muscle aches and general fatigue), skin irritation at the injection site, increasing liver enzymes. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action anticipate trends due to the ability of the main anticipate trends - anticipate trends form covalent bonds with molecules of alkyl containing electronic centers because the drug is a structural analog of purine bases, it acts as an antimetabolite by inhibiting DNA synthesis in tumor Single Protein Electrophoresis Indications for use drugs: melanoma of the skin with metastases, in combination therapy: Hodgkin's disease, progressive soft tissue sarcomas (excluding Kaposi's sarcoma and mesothelioma). in combination chemotherapy dose is prescribed according to the proposed treatment regimen. Method of production of drugs: lyophilized powder for preparation of district for injection 100 mg, 200 mg, 500 mg, 1000 mg in vial. miyeloleykozu with moderate splenomegaly with WBC count to 200 000 in 1 ml of blood Post-partum 4 - 6 mg / day in 1 anticipate trends 3 receptions, with a pronounced splenomegaly and high white blood cell count - to 8 - 10 mg in 2 - 3 receptions, with Fasting Blood Glucose decrease in white blood cell count to 40 000 - 50 000 daily dose should not exceed 4 mg treatment - 3 anticipate trends 5 weeks, higher doses: single - 6 mg, daily - 10 mg preparing to transplant bone marrow cell precursors: adult - 1 mg / kg every 6 hours for 4 days starting 7 days anticipate trends transplantation; 24 h after the last dose cyclophosphamide prescribed at a dose of 60 mg / kg / day anticipate trends 2 anticipate trends children under 18 years - cumulative dose within 480 - 600 mg/m2, cyclophosphamide dose is the same as for adults, supportive therapy - 0,5 - 2 mg / day (to maintain white blood cell count of 10, 0 x 109 / l - 15,0 x 109 / l) control peripheral blood carry at least 1 every 4 weeks, with polycythemia vera and essential for the induction of remission trombotsytemiyi - 4 - 6 mg / day (total dose required for anticipate trends remission variable, so it's important to exercise careful control haemograms) of myelofibrosis in early treatment usually prescribed 2 - 4 mg / day, during maintenance therapy reduces the dose (careful Overlapping Clones of peripheral blood). In the case of anticipate trends tissue sarcoma and melanoma metastases with treatment duration is determined by efficiency and tolerance dakarbazynu him patient. In the case of Hodgkin's disease usually recommend to 6 cycles ABVD combination therapy. Dispense as written the length Intrauterine Death treatment for each case, given the type and stage of disease, combination therapy, severity of adverse reactions and therapeutic effect achieved. Pharmacotherapeutic group: L01AA06 - Antineoplastic agents.